Ontology highlight
ABSTRACT:
SUBMITTER: Gaber ZB
PROVIDER: S-EPMC3792860 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Gaber Zachary B ZB Butler Samantha J SJ Novitch Bennett G BG
PLoS biology 20131008 10
Distinct classes of neurons and glial cells in the developing spinal cord arise at specific times and in specific quantities from spatially discrete neural progenitor domains. Thus, adjacent domains can exhibit marked differences in their proliferative potential and timing of differentiation. However, remarkably little is known about the mechanisms that account for this regional control. Here, we show that the transcription factor Promyelocytic Leukemia Zinc Finger (PLZF) plays a critical role s ...[more]