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Genome-wide association study of liver enzymes in korean children.

ABSTRACT: Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits; however, the genetic architecture in childhood remains largely unknown. We performed a genome-wide association study to identify new genetic loci for liver enzyme levels in a Korean childhood cohort (n = 484). We observed three novel loci (rs4949718, rs80311637, and rs596406) that were multiply associated with elevated levels of alanine transaminase and aspartate transaminase. Although there are some limitations, including genetic power, additional replication and functional characterization will support the clarity on the genetic contribution that the ST6GALNAC3, ADAMTS9, and CELF2 genes have in childhood liver function.

SUBMITTER: Park TJ

PROVIDER: S-EPMC3794088 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Genome-wide association study of liver enzymes in korean children.

Park Tae-Joon TJ Hwang Joo-Yeon JY Go Min Jin MJ Lee Hye-Ja HJ Jang Han Byul HB Choi Youngshim Y Kang Jae Heon JH Park Kyung Hee KH Choi Min-Gyu MG Song Jihyun J Kim Bong-Jo BJ Lee Jong-Young JY

Genomics & informatics 20130930 3

Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits; however, the genetic architecture in childhood remains largely unknown. We performed a genome-wide association study to identify new genetic loci for liver enzyme levels in a Korean childhood cohort (n = 484). We observed three novel loci (rs4949718, ...[more]

PMID: 24124411

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A genome-wide association study on liver enzymes in Korean population.

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