Ontology highlight
ABSTRACT:
SUBMITTER: Gayathri P
PROVIDER: S-EPMC3794156 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Gayathri Pananghat P Fujii Takashi T Namba Keiichi K Löwe Jan J
Journal of structural biology 20130224 1
The actin-like protein ParM forms the cytomotive filament of the ParMRC system, a type II plasmid segregation system encoded by Escherichia coli R1 plasmid. We report an 8.5Å resolution reconstruction of the ParM filament, obtained using cryo-electron microscopy. Fitting of the 3D density reconstruction with monomeric crystal structures of ParM provides insights into dynamic instability of ParM filaments. The structural analysis suggests that a ParM conformation, corresponding to a metastable st ...[more]