Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC3794359 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Xu H H Zhang X X Wang H H Zhang Y Y Shi Y Y Zhang X X
European journal of histochemistry : EJH 20130925 3
The normal ANK protein has a strong influence on anti-calcification. It is known that TGF-β1 is also able to induce extracellular inorganic pyrophosphate (ePPi) elaboration via the TGF-β1-induced ank gene expression and the mitogen-activated protein kinase (MAPK) signaling acts as a downstream effector of TGF-β1. We hypothesized that the expression of the ank gene is regulated by mechanics through TGF-β1-p38 pathway. In this study, we investigated the mechanism of short-time mechanical tension-i ...[more]