Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC3794577 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Liu Jing J Pendergraff Hannah H Narayanannair K Jayaprakash KJ Lackey Jeremy G JG Kuchimanchi Satya S Rajeev Kallanthottathil G KG Manoharan Muthiah M Hu Jiaxin J Corey David R DR
Nucleic acids research 20130724 18
Abasic substitutions within DNA or RNA are tools for evaluating the impact of absent nucleobases. Because of the importance of abasic sites in genetic damage, most research has involved DNA. Little information is available on the impact of abasic substitutions within RNA or on RNA interference (RNAi). Here, we examine the effect of abasic substitutions on RNAi and allele-selective gene silencing. Huntington's disease (HD) and Machado Joseph Disease (MJD) are severe neurological disorders that cu ...[more]