Ontology highlight
ABSTRACT:
SUBMITTER: Rhee JK
PROVIDER: S-EPMC3794600 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Rhee Je-Keun JK Kim Kwangsoo K Chae Heejoon H Evans Jared J Yan Pearlly P Zhang Byoung-Tak BT Gray Joe J Spellman Paul P Huang Tim H-M TH Nephew Kenneth P KP Kim Sun S
Nucleic acids research 20130724 18
Aberrant DNA methylation of CpG islands, CpG island shores and first exons is known to play a key role in the altered gene expression patterns in all human cancers. To date, a systematic study on the effect of DNA methylation on gene expression using high resolution data has not been reported. In this study, we conducted an integrated analysis of MethylCap-sequencing data and Affymetrix gene expression microarray data for 30 breast cancer cell lines representing different breast tumor phenotypes ...[more]