Ontology highlight
ABSTRACT:
SUBMITTER: Aeschbacher T
PROVIDER: S-EPMC3794610 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Aeschbacher Thomas T Schmidt Elena E Blatter Markus M Maris Christophe C Duss Olivier O Allain Frédéric H-T FH Güntert Peter P Schubert Mario M
Nucleic acids research 20130805 18
The three-dimensional structure determination of RNAs by NMR spectroscopy relies on chemical shift assignment, which still constitutes a bottleneck. In order to develop more efficient assignment strategies, we analysed relationships between sequence and (1)H and (13)C chemical shifts. Statistics of resonances from regularly Watson-Crick base-paired RNA revealed highly characteristic chemical shift clusters. We developed two approaches using these statistics for chemical shift assignment of doubl ...[more]