Ontology highlight
ABSTRACT:
SUBMITTER: Lum LG
PROVIDER: S-EPMC3794673 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Lum Lawrence G LG Thakur Archana A Liu Qin Q Deol Abhinav A Al-Kadhimi Zaid Z Ayash Lois L Abidi Muneer H MH Pray Cassara C Tomaszewski Elyse N EN Steele Patricia A PA Schalk Dana L DL Yano Hiroshi H Mitchell Alice A Dufresne Melissa M Uberti Joseph P JP Ratanatharathorn Voravit V
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20130322 6
A phase I trial of infusing anti-CD3 × anti-CD20 bispecific antibody (CD20Bi) armed activated T cells (aATC) was conducted in high-risk/refractory non-Hodgkin's lymphoma patients to determine whether aATC infusions are safe, affect immune recovery, and induce an antilymphoma effect. Ex vivo expanded ATC from 12 patients were armed with anti-CD20 bispecific antibody, cryopreserved, and infused after autologous stem cell transplantation (SCT). Patients underwent SCT after high-dose chemotherapy, a ...[more]