Ontology highlight
ABSTRACT:
SUBMITTER: Zhang K
PROVIDER: S-EPMC3794710 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Nature cell biology 20130505 6
Increased stromal collagen deposition in human breast tumours correlates with metastases. We show that activation of the collagen I receptor DDR2 (discoidin domain receptor 2) regulates SNAIL1 stability by stimulating ERK2 activity, in a Src-dependent manner. Activated ERK2 directly phosphorylates SNAIL1, leading to SNAIL1 nuclear accumulation, reduced ubiquitylation and increased protein half-life. DDR2-mediated stabilization of SNAIL1 promotes breast cancer cell invasion and migration in vitro ...[more]