Celf1 is required for formation of endoderm-derived organs in zebrafish.
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ABSTRACT:
SUBMITTER: Tahara N
PROVIDER: S-EPMC3794766 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Celf1 is required for formation of endoderm-derived organs in zebrafish.
Tahara Naoyuki N Bessho Yasumasa Y Matsui Takaaki T
International journal of molecular sciences 20130903 9
We recently reported that an RNA binding protein called Cugbp Elav-like family member 1 (Celf1) regulates somite symmetry and left-right patterning in zebrafish. In this report, we show additional roles of Celf1 in zebrafish organogenesis. When celf1 is knocked down by using an antisense morpholino oligonucleotides (MO), liver buds fail to form, and pancreas buds do not form a cluster, suggesting earlier defects in endoderm organogenesis. As expected, we found failures in endoderm cell growth an ...[more]
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