Ontology highlight
ABSTRACT:
SUBMITTER: Nasman A
PROVIDER: S-EPMC3794938 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Näsman Anders A Andersson Emilia E Marklund Linda L Tertipis Nikolaos N Hammarstedt-Nordenvall Lalle L Attner Per P Nyberg Tommy T Masucci Giuseppe V GV Munck-Wikland Eva E Ramqvist Torbjörn T Dalianis Tina T
PloS one 20131010 10
HPV-DNA positive (HPVDNA+) oropharyngeal squamous cell carcinoma (OSCC) has better clinical outcome than HPV-DNA negative (HPVDNA-) OSCC. Current treatment may be unnecessarily extensive for most HPV+ OSCC, but before de-escalation, additional markers are needed together with HPV status to better predict treatment response. Here the influence of HLA class I/HLA class II expression was explored. Pre-treatment biopsies, from 439/484 OSCC patients diagnosed 2000-2009 and treated curatively, were an ...[more]