Ontology highlight
ABSTRACT:
SUBMITTER: Kurita S
PROVIDER: S-EPMC3795237 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Kurita Souichi S Yamada Tomohiro T Rikitsu Etsuko E Ikeda Wataru W Takai Yoshimi Y
The Journal of biological chemistry 20130829 41
Adherens junction (AJ) is a specialized cell-cell junction structure that plays a role in mechanically connecting adjacent cells to resist strong contractile forces and to maintain tissue structure, particularly in the epithelium. AJ is mainly comprised of cell adhesion molecules cadherin and nectin and their associating cytoplasmic proteins including β-catenin, α-catenin, p120(ctn), and afadin. Our series of studies have revealed that nectin first forms cell-cell adhesion and then recruits cadh ...[more]