Ontology highlight
ABSTRACT:
SUBMITTER: Okada T
PROVIDER: S-EPMC3795355 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Okada Tomoko T Murata Kazuhiro K Hirose Ryoma R Matsuda Chie C Komatsu Tsunehiko T Ikekita Masahiko M Nakawatari Miyako M Nakayama Fumiaki F Wakatsuki Masaru M Ohno Tatsuya T Kato Shingo S Imai Takashi T Imamura Toru T
Scientific reports 20131011
Cancer cells often develop drug resistance. In cisplatin-resistant HeLa cisR cells, fibroblast growth factor 13 (FGF13/FHF2) gene and protein expression was strongly upregulated, and intracellular platinum concentrations were kept low. When the FGF13 expression was suppressed, both the cells' resistance to platinum drugs and their ability to keep intracellular platinum low were abolished. Overexpression of FGF13 in parent cells led to greater resistance to cisplatin and reductions in the intrace ...[more]