Ontology highlight
ABSTRACT:
SUBMITTER: Fukushima K
PROVIDER: S-EPMC3795561 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Fukushima Kei K Kamimura Takashi T Takimoto-Kamimura Midori M
Journal of synchrotron radiation 20130929 Pt 6
SLPI (secretory leukocyte protease inhibitor) is a 107-residue protease inhibitor which inhibits various serine proteases, including elastase, cathepsin G, chymotrypsin and trypsin. SLPI is obtained as a multiple inhibitor in lung defense and in chronic airway infection. X-ray crystal structures have so far reported that they are full-length SLPIs with bovine α-chymotrypsin and 1/2SLPI (recombinant C-terminal domain of SLPI; Arg58-Ala107) with HNE (human neutrophil elastase). To understand the r ...[more]