Genetic control of spontaneous arthritis in a four-way advanced intercross line.
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ABSTRACT:
SUBMITTER: Ranea LM
PROVIDER: S-EPMC3795728 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Genetic control of spontaneous arthritis in a four-way advanced intercross line.
Ranea Laura Mellado LM de Castro Marques Andreia A Möller Steffen S Gupta Yask Y Ibrahim Saleh M SM
PloS one 20131011 10
Identifying the genetic basis of complex diseases, such as rheumatoid arthritis, remains a challenge that requires experimental models to reduce the genetic and environmental variability. Numerous loci for arthritis have been identified in induced animal models; however, few spontaneous models have been genetically studied. Therefore, we generated a four-way advanced intercross line (AIL) from four inbred strains, including BXD2/TyJ which spontaneously develops autoimmune arthritis. A genome-wid ...[more]
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