Ontology highlight
ABSTRACT:
SUBMITTER: Wei K
PROVIDER: S-EPMC3795838 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Wei Kevin K Piecewicz Stephanie M SM McGinnis Lisa M LM Taniguchi Cullen M CM Wiegand Stanley J SJ Anderson Keith K Chan Carol W-M CW Mulligan Kimberly X KX Kuo David D Yuan Jenny J Vallon Mario M Morton Lori L Lefai Etienne E Simon M Celeste MC Maher Jacquelyn J JJ Mithieux Gilles G Rajas Fabienne F Annes Justin J McGuinness Owen P OP Thurston Gavin G Giaccia Amato J AJ Kuo Calvin J CJ
Nature medicine 20130915 10
Insulin initiates diverse hepatic metabolic responses, including gluconeogenic suppression and induction of glycogen synthesis and lipogenesis. The liver possesses a rich sinusoidal capillary network with a higher degree of hypoxia and lower gluconeogenesis in the perivenous zone as compared to the rest of the organ. Here, we show that diverse vascular endothelial growth factor (VEGF) inhibitors improved glucose tolerance in nondiabetic C57BL/6 and diabetic db/db mice, potentiating hepatic insul ...[more]