Dataset Information

Asthma and risk of non-respiratory tract infection: a population-based case-control study.

ABSTRACT:

Objectives

Asthmatics have increased risks of airway-related infections. Little is known about whether this is true for non-airway-related serious infections such as Escherichia coli bloodstream infection (BSI). We assessed whether asthma is associated with a risk of developing community-acquired E coli BSI.

Design

The study was designed as a population-based retrospective case-control study.

Setting

This population-based study was conducted in Olmsted County, Minnesota.

Participants

The study included 259 all eligible community-acquired E coli BSI cases in Olmsted County, MN between 1998 and 2007 and 259 birthday-matched, gender-matched and residency-matched controls.

Primary and secondary outcome measures

Only community-acquired E coli BSI cases as the primary outcome was included. Asthma status as an exposure was ascertained by predetermined criteria. An adjusted OR and 95% CI for the association between asthma and risk of community-acquired E coli BSI was calculated using conditional logistic regression.

Results

Of 259 eligible cases, 179 (69%) were women and mean age was 61±22 years. Of the 259 cases 37 (14%) and 16 (6%) of 259 controls had a prior history of asthma (adjusted OR 2.74; 95% CI 1.11 to 6.76; p=0.029). The population attributable risk of asthma for community-acquired E coli BSI was 9%. Although not statistically significant, there was a borderline association between having a history of food allergy and increased risk of community-acquired E coli BSI (6% vs 2%; adjusted OR 3.51; 95% CI 0.94 to 13.11; p=0.062).

Conclusions

Based on the findings of the current population-based, case-control investigation, a history of asthma may be associated with risk of community-acquired E coli BSI. The impact of asthma on risk of microbial infections may go beyond airways.

SUBMITTER: Bang DW

PROVIDER: S-EPMC3796274 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Asthma and risk of non-respiratory tract infection: a population-based case-control study.

Bang Duk Won DW Yang Hyeon J HJ Ryoo Eell E Al-Hasan Majdi N MN Lahr Brian B Baddour Larry M LM Yawn Barbara P BP Juhn Young J YJ

BMJ open 20131003 10

<h4>Objectives</h4>Asthmatics have increased risks of airway-related infections. Little is known about whether this is true for non-airway-related serious infections such as Escherichia coli bloodstream infection (BSI). We assessed whether asthma is associated with a risk of developing community-acquired E coli BSI.<h4>Design</h4>The study was designed as a population-based retrospective case-control study.<h4>Setting</h4>This population-based study was conducted in Olmsted County, Minnesota.<h4 ...[more]

PMID: 24091424

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Dataset Information

Asthma and risk of non-respiratory tract infection: a population-based case-control study.

Objectives

Design

Setting

Participants

Primary and secondary outcome measures

Results

Conclusions

Publications

Asthma and risk of non-respiratory tract infection: a population-based case-control study.

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