Ontology highlight
ABSTRACT:
SUBMITTER: Bailey KM
PROVIDER: S-EPMC3796340 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Bailey Kate M KM Wojtkowiak Jonathan W JW Hashim Arig Ibrahim AI Gillies Robert J RJ
Advances in pharmacology (San Diego, Calif.) 20120101
The observation of aerobic glycolysis by tumor cells in 1924 by Otto Warburg, and subsequent innovation of imaging glucose uptake by tumors in patients with PET-CT, has incited a renewed interest in the altered metabolism of tumors. As tumors grow in situ, a fraction of it is further away from their blood supply, leading to decreased oxygen concentrations (hypoxia), which induces the hypoxia response pathways of HIF1α, mTOR, and UPR. In normal tissues, these responses mitigate hypoxic stress and ...[more]