Expression of the placental transcriptome in maternal nutrient reduction in baboons is dependent on fetal sex.

ABSTRACT: Maternal undernutrition increases the risk of perinatal complications and predisposes offspring to obesity, diabetes, and cardiovascular disease later in life. Emerging evidence suggests that changes in placental function play a role in linking altered maternal nutrition in pregnancy to the subsequent development of adult disease. The susceptibility for disease in response to an adverse intrauterine environment differs distinctly between boys and girls, with girls typically having better outcomes. Here, we tested the hypothesis that regulation of the placental transcriptome by maternal nutrient reduction (NR) is dependent on fetal sex. We used a nonhuman primate model of NR in which maternal global food intake was reduced by 30% in baboons starting at gestational day (GD) 30. At GD 165 (te

SUBMITTER: Cox LA 

PROVIDER: S-EPMC3796342 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature