Ontology highlight
ABSTRACT:
SUBMITTER: Serafini A
PROVIDER: S-EPMC3796483 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Serafini Agnese A Pisu Davide D Palù Giorgio G Rodriguez G Marcela GM Manganelli Riccardo R
PloS one 20131014 10
ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and its involvement in the adaptation to low zinc environment in M. tuberculosis. Moreover, we unveiled functional differences between the ESX-3 roles in M. tuberculosis and M. smegmatis showing that in th ...[more]