Unknown

Dataset Information

0

Exploration of miRNA families for hypotheses generation.


ABSTRACT: Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhance investigation of characteristics of miRNA families and the functions of family-specific miRNA genes are lacking. We have developed, miRNAVISA, a user-friendly web-based tool that allows customized interrogation and comparisons of miRNA families for hypotheses generation, and comparison of per-species chromosomal distribution of miRNA genes in different families. This study illustrates hypothesis generation using miRNAVISA in seven species. Our results unveil a subclass of miRNAs that may be regulated by genomic imprinting, and also suggest that some miRNA families may be species-specific, as well as chromosome- and/or strand-specific.

SUBMITTER: Kamanu TK 

PROVIDER: S-EPMC3796740 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Exploration of miRNA families for hypotheses generation.

Kamanu Timothy K K TK   Radovanovic Aleksandar A   Archer John A C JA   Bajic Vladimir B VB  

Scientific reports 20131015


Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhance investigation of characteristics of miRNA families and the functions of family-specific miRNA genes are lacking. We have developed, miRNAVISA, a user-friendly web-based tool that  ...[more]

Similar Datasets

| S-EPMC7206271 | biostudies-literature
| S-EPMC6708313 | biostudies-other
| S-EPMC3136923 | biostudies-literature
| S-EPMC4336146 | biostudies-literature
| S-EPMC8268298 | biostudies-literature
| S-EPMC3749189 | biostudies-literature
| S-EPMC8487426 | biostudies-literature
| S-EPMC8186779 | biostudies-literature
| S-EPMC3448685 | biostudies-literature
| S-EPMC4447459 | biostudies-literature