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Clinical impact of recent genetic discoveries in osteoporosis.

ABSTRACT: Osteoporotic fracture carries an enormous public health burden in terms of mortality and morbidity. Current approaches to identify individuals at high risk for fracture are based on assessment of bone mineral density and presence of other osteoporosis risk factors. Bone mineral density and susceptibility to osteoporotic fractures are highly heritable, and over 60 loci have been robustly associated with one or both traits through genome-wide association studies carried out over the past 7 years. In this review, we discuss opportunities and challenges for incorporating these genetic discoveries into strategies to prevent osteoporotic fracture and translating new insights obtained from these discoveries into development of new therapeutic targets.

SUBMITTER: Mitchell BD

PROVIDER: S-EPMC3796859 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Clinical impact of recent genetic discoveries in osteoporosis.

Mitchell Braxton D BD Streeten Elizabeth A EA

The application of clinical genetics 20131004

Osteoporotic fracture carries an enormous public health burden in terms of mortality and morbidity. Current approaches to identify individuals at high risk for fracture are based on assessment of bone mineral density and presence of other osteoporosis risk factors. Bone mineral density and susceptibility to osteoporotic fractures are highly heritable, and over 60 loci have been robustly associated with one or both traits through genome-wide association studies carried out over the past 7 years. ...[more]

PMID: 24133373

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