Ontology highlight
ABSTRACT:
SUBMITTER: Marini F
PROVIDER: S-EPMC3797002 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Marini Francesca F Parri Simone S Masi Laura L Ciuffi Simone S Guazzini Andrea A Fabbri Sergio S Luzi Ettore E Cianferotti Luisella L Brandi Maria Luisa ML
Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 20130501 2
<h4>Background</h4>Osteoporosis is the most common metabolic bone disorder of the elderly, affecting the normal bone turnover with an increased bone resorption and subsequent higher risk of fragility fractures. Collagen type 1 is the most represented protein in bone matrix. A genetic variation (Sp1) in intron 1 of COL1A1 gene has been associated to modulation of expression of the alpha 1 chain of collagen type 1 and it is considered a candidate polymorphism for predisposition to osteoporosis sta ...[more]