IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis.
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ABSTRACT:
SUBMITTER: Nakayama M
PROVIDER: S-EPMC3797434 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis.
Nakayama Masanori M Niki Yasuo Y Kawasaki Toshiki T Takeda Yuki Y Ikegami Hiroyasu H Toyama Yoshiaki Y Miyamoto Takeshi T
Scientific reports 20131016
Interleukin (IL)-32 is known to exert adujvant effects on innate immune response, however, receptors and downstream signaling pathways remain to be clarified. Here we found that IL-32γ upregulated serine protease activity of proteinase-3 (PR3), in turn triggering protease-activated receptor 2 (PAR2) signaling. Interestingly, silencing of PR3 or PAR2 using siRNA markedly diminished IL-32γ-induced TNFα and IFN-β mRNA expression. IL-32γ-PAR2 axis utilized TRIF and Ras-Raf-1 pathways. On stimulation ...[more]
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