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Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.

ABSTRACT: Bcl-2 family of proteins consists of both pro-apoptotic and anti-apoptotic members that control cellular apoptosis. They predominantly reside in the mitochondria and control the release of apoptotic factors from the mitochondria to the cytosol by regulating its membrane potential and opening the PT (permeability transition) pore. Here we report bioinformatics and biochemical evidence to demonstrate the interaction between Bcl-2 and Bcl-xL with a stress chaperone, mortalin. We demonstrate that such interaction results in the abrogation of mortalin-p53 interaction leading to nuclear translocation and transcriptional reactivation of p53 function that results in an induction of senescence in cancer cells.

SUBMITTER: Saxena N

PROVIDER: S-EPMC3797589 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.

Saxena Nishant N Katiyar Shashank P SP Liu Ye Y Grover Abhinav A Gao Ran R Sundar Durai D Kaul Sunil C SC Wadhwa Renu R

Bioscience reports 20131016 5

Bcl-2 family of proteins consists of both pro-apoptotic and anti-apoptotic members that control cellular apoptosis. They predominantly reside in the mitochondria and control the release of apoptotic factors from the mitochondria to the cytosol by regulating its membrane potential and opening the PT (permeability transition) pore. Here we report bioinformatics and biochemical evidence to demonstrate the interaction between Bcl-2 and Bcl-xL with a stress chaperone, mortalin. We demonstrate that su ...[more]

PMID: 24050266

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