Confidence-guided local structure prediction with HHfrag.
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ABSTRACT:
SUBMITTER: Kalev I
PROVIDER: S-EPMC3797814 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Confidence-guided local structure prediction with HHfrag.
PloS one 20131016 10
We present a method to assess the reliability of local structure prediction from sequence. We introduce a greedy algorithm for filtering and enrichment of dynamic fragment libraries, compiled with remote-homology detection methods such as HHfrag. After filtering false hits at each target position, we reduce the fragment library to a minimal set of representative fragments, which are guaranteed to have correct local structure in regions of detectable conservation. We demonstrate that the location ...[more]
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