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Back-scatter based whispering gallery mode sensing.

ABSTRACT: Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive real-time observation of motor molecule motion. However, to date technical noise sources, most particularly low frequency laser noise, have constrained such applications. Here we introduce a new technique for whispering gallery mode sensing based on direct detection of back-scattered light. This experimentally straightforward technique is immune to frequency noise in principle, and further, acts to suppress thermorefractive noise. We demonstrate 27 dB of frequency noise suppression, eliminating frequency noise as a source of sensitivity degradation and allowing an absolute frequency shift sensitivity of 76 kHz. Our results open a new pathway towards single molecule biophysics experiments and ultrasensitive biosensors.

SUBMITTER: Knittel J

PROVIDER: S-EPMC3797986 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Back-scatter based whispering gallery mode sensing.

Knittel Joachim J Swaim Jon D JD McAuslan David L DL Brawley George A GA Bowen Warwick P WP

Scientific reports 20131017

Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive real-time observation of motor molecule motion. However, to date technical noise sources, most particularly low frequency laser noise, have constrained such applications. Here we introduce a new technique for whispering gallery mode sensing based on direct detection of back-scattered light. This experimentally straightforward t ...[more]

PMID: 24131939

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