Ontology highlight
ABSTRACT:
SUBMITTER: Hu L
PROVIDER: S-EPMC3798070 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Hu Lei L Joshi Sangeeta B SB Andra Kiran K KK Thakkar Santosh V SV Volkin David B DB Bann James G JG Middaugh C Russell CR
Journal of pharmaceutical sciences 20120821 11
Protective antigen (PA) is the primary protein antigenic component of both the currently used anthrax vaccine and related recombinant vaccines under development. An analogue of recombinant PA (2-FHis rPA) has been recently shown to block the key steps of pore formation in the process of inducing cytotoxicity in cells, and thus can potentially be used as an antitoxin or a vaccine. This rPA analogue was produced by fermentation to incorporate the unnatural amino acid 2-fluorohistidine (2-FHis). In ...[more]