Ontology highlight
ABSTRACT:
SUBMITTER: Quintavalle C
PROVIDER: S-EPMC3798259 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Quintavalle Cristina C Mangani Davide D Roscigno Giuseppina G Romano Giulia G Diaz-Lagares Angel A Iaboni Margherita M Donnarumma Elvira E Fiore Danilo D De Marinis Pasqualino P Soini Ylermi Y Esteller Manel M Condorelli Gerolama G
PloS one 20130919 9
Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of temozolomide (TMZ) in combination with radiotherapy. Much evidence suggests that the intracellular level of the alkylating enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) impacts response to TMZ in GBM patients. MGMT expression is regulated by the methylation of its promoter. However, evidence indicates that this is not the only regulator ...[more]