Ontology highlight
ABSTRACT:
SUBMITTER: Gylfe AE
PROVIDER: S-EPMC3798264 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Gylfe Alexandra E AE Katainen Riku R Kondelin Johanna J Tanskanen Tomas T Cajuso Tatiana T Hänninen Ulrika U Taipale Jussi J Taipale Minna M Renkonen-Sinisalo Laura L Järvinen Heikki H Mecklin Jukka-Pekka JP Kilpivaara Outi O Pitkänen Esa E Vahteristo Pia P Tuupanen Sari S Karhu Auli A Aaltonen Lauri A LA
PLoS genetics 20131017 10
Hereditary factors are presumed to play a role in one third of colorectal cancer (CRC) cases. However, in the majority of familial CRC cases the genetic basis of predisposition remains unexplained. This is particularly true for families with few affected individuals. To identify susceptibility genes for this common phenotype, we examined familial cases derived from a consecutive series of 1514 Finnish CRC patients. Ninety-six familial CRC patients with no previous diagnosis of a hereditary CRC s ...[more]