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Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity.


ABSTRACT:

Purpose

The combination of a platinum and taxane are standard of care for many cancers, but the utility is often limited due to debilitating neurotoxicity. We examined whether single-nucleotide polymorphisms (SNP) from annotated candidate genes will identify genetic risk for chemotherapy-induced neurotoxicity.

Patients and methods

A candidate-gene association study was conducted to validate the relevance of 1,261 SNPs within 60 candidate genes in 404 ovarian cancer patients receiving platinum/taxane chemotherapy on the SCOTROC1 trial. Statistically significant variants were then assessed for replication in a separate 404 patient replication cohort from SCOTROC1.

Results

Significant associations with chemotherapy-induced neurotoxicity were identified and replicated for four SNPs in SOX10, BCL2, OPRM1, and TRPV1. The population attributable risk for each of the four SNPs ranged from 5% to 35%, with a cumulative risk of 62%. According to the multiplicative model, the odds of developing neurotoxicity increase by a factor of 1.64 for every risk genotype. Patients possessing three risk variants have an estimated OR of 4.49 (2.36-8.54) compared to individuals with 0 risk variants. Neither the four SNPs nor the risk score were associated with progression-free survival or overall survival.

Conclusions

This study shows that SNPs in four genes have a significant cumulative association with increased risk for the development of chemotherapy-induced neurotoxicity, independent of patient survival.

SUBMITTER: McWhinney-Glass S 

PROVIDER: S-EPMC3798385 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Publications

Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity.

McWhinney-Glass Sarah S   Winham Stacey J SJ   Hertz Daniel L DL   Yen Revollo Jane J   Paul Jim J   He Yijing Y   Brown Robert R   Motsinger-Reif Alison A AA   McLeod Howard L HL  

Clinical cancer research : an official journal of the American Association for Cancer Research 20130820 20


<h4>Purpose</h4>The combination of a platinum and taxane are standard of care for many cancers, but the utility is often limited due to debilitating neurotoxicity. We examined whether single-nucleotide polymorphisms (SNP) from annotated candidate genes will identify genetic risk for chemotherapy-induced neurotoxicity.<h4>Patients and methods</h4>A candidate-gene association study was conducted to validate the relevance of 1,261 SNPs within 60 candidate genes in 404 ovarian cancer patients receiv  ...[more]

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