Molecular basis for oligomeric-DNA binding and episome maintenance by KSHV LANA.
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ABSTRACT:
SUBMITTER: Domsic JF
PROVIDER: S-EPMC3798644 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Molecular basis for oligomeric-DNA binding and episome maintenance by KSHV LANA.
Domsic John F JF Chen Horng-Shen HS Lu Fang F Marmorstein Ronen R Lieberman Paul M PM
PLoS pathogens 20131017 10
LANA is the KSHV-encoded terminal repeat binding protein essential for viral replication and episome maintenance during latency. We have determined the X-ray crystal structure of LANA C-terminal DNA binding domain (LANADBD) to reveal its capacity to form a decameric ring with an exterior DNA binding surface. The dimeric core is structurally similar to EBV EBNA1 with an N-terminal arm that regulates DNA binding and is required for replication function. The oligomeric interface between LANA dimers ...[more]
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