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The clinical implication of SS18-SSX fusion gene in synovial sarcoma.

ABSTRACT:

Background

The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China.

Methods

We collected and analysed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasion.

Results

Overall survival was significantly better among SS18-SSX2 cases (P=0.001), FNCLCC grade 2 cases (P<0.001), and UICC stage 1 or 2 (P<0.001) by univariate and multivariate survival analysis. SS18-SSX1-positive cells were more proliferative and invasive than SS18-SSX2-positive cells.

Conclusion

SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma.

SUBMITTER: Ren T

PROVIDER: S-EPMC3798954 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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The clinical implication of SS18-SSX fusion gene in synovial sarcoma.

Ren T T Lu Q Q Guo W W Lou Z Z Peng X X Jiao G G Sun Y Y

British journal of cancer 20130910 8

<h4>Background</h4>The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China.<h4>Methods</h4>We collected and analysed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasion.<h4>Results</h4>Overall survi ...[more]

PMID: 24022186

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