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The clinical implication of SS18-SSX fusion gene in synovial sarcoma.

ABSTRACT: BACKGROUND: The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China. METHODS: We collected and analysed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasion. RESULTS: Overall survival was significantly better among SS18-SSX2 cases (P=0.001), FNCLCC grade 2 cases (P<0.001), and UICC stage 1 or 2 (P<0.001) by univariate and multivariate survival analysis. SS18-SSX1-positive cells were more proliferative and invasive than SS18-SSX2-positive cells. CONCLUSION: SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma.

SUBMITTER: Ren T

PROVIDER: S-EPMC3798954 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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The clinical implication of SS18-SSX fusion gene in synovial sarcoma.

Ren T T Lu Q Q Guo W W Lou Z Z Peng X X Jiao G G Sun Y Y

British journal of cancer 20130910 8

<h4>Background</h4>The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China.<h4>Methods</h4>We collected and analysed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasion.<h4>Results</h4>Overall survi ...[more]

PMID: 24022186

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