Ontology highlight
ABSTRACT:
SUBMITTER: Beurlet S
PROVIDER: S-EPMC3799000 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Beurlet Stephanie S Omidvar Nader N Gorombei Petra P Krief Patricia P Le Pogam Carole C Setterblad Niclas N de la Grange Pierre P Leboeuf Christophe C Janin Anne A Noguera Maria-Elena ME Hervatin Florence F Sarda-Mantel Laure L Konopleva Marina M Andreeff Michael M Tu Andrea W AW Fan Alice C AC Felsher Dean W DW Whetton Anthony A Pla Marika M West Robert R Fenaux Pierre P Chomienne Christine C Padua Rose Ann RA
Blood 20130813 16
Myelodysplastic syndrome (MDS) transforms into an acute myelogenous leukemia (AML) with associated increased bone marrow (BM) blast infiltration. Using a transgenic mouse model, MRP8[NRASD12/hBCL-2], in which the NRAS:BCL-2 complex at the mitochondria induces MDS progressing to AML with dysplastic features, we studied the therapeutic potential of a BCL-2 homology domain 3 mimetic inhibitor, ABT-737. Treatment significantly extended lifespan, increased survival of lethally irradiated secondary re ...[more]