Ontology highlight
ABSTRACT:
SUBMITTER: Pandey RR
PROVIDER: S-EPMC3799322 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Pandey Radha Raman RR Tokuzawa Yoshimi Y Yang Zhaolin Z Hayashi Eri E Ichisaka Tomoko T Kajita Shimpei S Asano Yuka Y Kunieda Tetsuo T Sachidanandam Ravi R Chuma Shinichiro S Yamanaka Shinya S Pillai Ramesh S RS
Proceedings of the National Academy of Sciences of the United States of America 20130925 41
Piwi-interacting RNAs (piRNAs) are gonad-specific small RNAs that provide defense against transposable genetic elements called transposons. Our knowledge of piRNA biogenesis is sketchy, partly due to an incomplete inventory of the factors involved. Here, we identify Tudor domain-containing 12 (TDRD12; also known as ECAT8) as a unique piRNA biogenesis factor in mice. TDRD12 is detected in complexes containing Piwi protein MILI (PIWIL2), its associated primary piRNAs, and TDRD1, all of which are a ...[more]