Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC3799423 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Yang Luhan L Guell Marc M Byrne Susan S Yang Joyce L JL De Los Angeles Alejandro A Mali Prashant P Aach John J Kim-Kiselak Caroline C Briggs Adrian W AW Rios Xavier X Huang Po-Yi PY Daley George G Church George G
Nucleic acids research 20130731 19
Efficient strategies for precise genome editing in human-induced pluripotent cells (hiPSCs) will enable sophisticated genome engineering for research and clinical purposes. The development of programmable sequence-specific nucleases such as Transcription Activator-Like Effectors Nucleases (TALENs) and Cas9-gRNA allows genetic modifications to be made more efficiently at targeted sites of interest. However, many opportunities remain to optimize these tools and to enlarge their spheres of applicat ...[more]