Ontology highlight
ABSTRACT:
SUBMITTER: Peng C
PROVIDER: S-EPMC3799458 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Peng Cheng C Fu Liang-Yu LY Dong Peng-Fei PF Deng Zhi-Luo ZL Li Jian-Xin JX Wang Xiao-Tao XT Zhang Hong-Yu HY
Nucleic acids research 20130821 19
The 3D chromatin structure modeling by chromatin interactions derived from Hi-C experiments is significantly challenged by the intrinsic sequencing biases in these experiments. Conventional modeling methods only focus on the bias among different chromatin regions within the same experiment but neglect the bias arising from different experimental sequencing depth. We now show that the regional interaction bias is tightly coupled with the sequencing depth, and we further identify a chromatin struc ...[more]