Ontology highlight
ABSTRACT:
SUBMITTER: Bardet AF
PROVIDER: S-EPMC3799470 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Bardet Anaïs F AF Steinmann Jonas J Bafna Sangeeta S Knoblich Juergen A JA Zeitlinger Julia J Stark Alexander A
Bioinformatics (Oxford, England) 20130824 21
<h4>Motivation</h4>Chromatin immunoprecipitation coupled to next-generation sequencing (ChIP-seq) is widely used to study the in vivo binding sites of transcription factors (TFs) and their regulatory targets. Recent improvements to ChIP-seq, such as increased resolution, promise deeper insights into transcriptional regulation, yet require novel computational tools to fully leverage their advantages.<h4>Results</h4>To this aim, we have developed peakzilla, which can identify closely spaced TF bin ...[more]