Ontology highlight
ABSTRACT:
SUBMITTER: Hampl V
PROVIDER: S-EPMC3799492 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Hampl Veronika V Martin Claudia C Aigner Achim A Hoebel Sabrina S Singer Stephan S Frank Natalie N Sarikas Antonio A Ebert Oliver O Prywes Ron R Gudermann Thomas T Muehlich Susanne S
EMBO molecular medicine 20130729 9
Megakaryoblastic leukaemia 1 and 2 (MKL1/2) are coactivators of the transcription factor serum response factor (SRF). Here, we provide evidence that depletion of MKL1 and 2 abolishes hepatocellular carcinoma (HCC) xenograft growth. Loss of the tumour suppressor deleted in liver cancer 1 (DLC1) and the subsequent activation of RhoA were prerequisites for MKL1/2 knockdown-mediated growth arrest. We identified oncogene-induced senescence as the molecular mechanism underlying the anti-proliferative ...[more]