Ontology highlight
ABSTRACT:
SUBMITTER: Lau P
PROVIDER: S-EPMC3799583 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Lau Pierre P Bossers Koen K Janky Rekin's R Salta Evgenia E Frigerio Carlo Sala CS Barbash Shahar S Rothman Roy R Sierksma Annerieke S R AS Thathiah Amantha A Greenberg David D Papadopoulou Aikaterini S AS Achsel Tilmann T Ayoubi Torik T Soreq Hermona H Verhaagen Joost J Swaab Dick F DF Aerts Stein S De Strooper Bart B
EMBO molecular medicine 20130909 10
An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late-onset AD (LOAD) patients and 23 controls, showing deregulation of 35 miRNAs. Profiling of miRNAs in the prefrontal cortex of a second independent cohort of 49 patients grouped by Braak stages revealed 41 deregulated miRNAs. We focused on miR-132-3p which is strongly altered in both brain areas. Downregulation of this miRNA occurs already at Braak stages III and IV, before ...[more]