Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets.
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ABSTRACT:
SUBMITTER: Mao H
PROVIDER: S-EPMC3799884 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets.
Mao Hua H Lebrun Drake G DG Yang Jingxuan J Zhu Vivian F VF Li Min M
Cancer investigation 20120101 1
Glioblastoma multiforme (GBM) is the most malignant and aggressive type of brain tumor with an average life expectancy of less than 15 months. This is mostly due to the highly mutated genome of GBM, which is characterized by the deregulation of many key signaling pathways involving growth, proliferation, survival, and apoptosis. It is critical to explore novel diagnostic and therapeutic strategies that target these pathways to improve the treatment of malignant glioma in the future. This review ...[more]
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