Ontology highlight
ABSTRACT:
SUBMITTER: Paugh BS
PROVIDER: S-EPMC3800209 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Paugh Barbara S BS Zhu Xiaoyan X Qu Chunxu C Endersby Raelene R Diaz Alexander K AK Zhang Junyuan J Bax Dorine A DA Carvalho Diana D Reis Rui M RM Onar-Thomas Arzu A Broniscer Alberto A Wetmore Cynthia C Zhang Jinghui J Jones Chris C Ellison David W DW Baker Suzanne J SJ
Cancer research 20130822 20
The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of HGG that arise in the brainstem almost exclusively in children. Genome-wide analyses of copy number imbalances previously showed that platelet-derived growth factor receptor α (PDGFRA) is the most frequent target of focal amplification in pediatric HGGs, including DIPGs. To determine whether PDGFRA is also targeted by ...[more]