Ontology highlight
ABSTRACT:
SUBMITTER: Ehrman LA
PROVIDER: S-EPMC3801072 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Ehrman Lisa A LA Mu Xiuqian X Waclaw Ronald R RR Yoshida Yutaka Y Vorhees Charles V CV Klein William H WH Campbell Kenneth K
Proceedings of the National Academy of Sciences of the United States of America 20130930 42
The mammalian striatum controls the output of the basal ganglia via two distinct efferent pathways, the direct (i.e., striatonigral) and the indirect (i.e., striatopallidal) pathways. The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in a subpopulation of striatal progenitors; however, its specific role in striatal development remains unknown. Our genetic fate-mapping results show that Isl1-expressing progenitors give rise to striatal neurons belonging to the striatonigral path ...[more]