A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3801116 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
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A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy.
Zhang Lianhai L Yang Jie J Cai Jie J Song Xiaoming X Deng Jianyun J Huang Xuesong X Chen Dawei D Yang Mengmeng M Wery Jean-Pierre JP Li Shuangxi S Wu Aiwen A Li Ziyu Z Li Zhongwu Z Liu Yiqiang Y Chen Yiyou Y Li Qixiang Q Ji Jiafu J
Scientific reports 20131021
A preclinical trial identified 4 of 20 (20%) gastric cancer (GC) patient-derived xenografts responded to cetuximab. Genome-wide profiling and additional investigations revealed that high EGFR mRNA expression and immunohistochemistry score (3+) are associated with tumor growth inhibition. Furthermore, EGFR amplification were observed in 2/4 (50%) responders with average copy number 5.8 and >15 respectively. Our data suggest that a GC subtype with EGFR amplification and overexpression benefit from ...[more]
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