Early life arsenic exposure and acute and long-term responses to influenza A infection in mice.
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ABSTRACT: Background
Arsenic is a significant global environmental health problem. Exposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase the rates of bronchiectasis in early adulthood.Objective
We aimed to determine if early life exposure to arsenic exacerbates the response to early life influenza infection in mice.Methods
C57BL/6 mice were exposed to arsenic in utero and throughout postnatal life. At 1 week of age, a subgroup of mice were infected with influenza A. We then assessed the acute and long-term effects of arsenic exposure on viral clearance, inflammation, lung structure, and lung function.Results
Early life arsenic exposure reduced the clearance of and exacerbated the inflammatory response to influenza A, and resulted in acute and long-term changes in lung mechanics and airway structure.Conclusions
Increased susceptibility to respiratory infections combined with exaggerated inflammatory responses throughout early life may contribute to the development of bronchiectasis in arsenic-exposed populations.
SUBMITTER: Ramsey KA
PROVIDER: S-EPMC3801203 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Early life arsenic exposure and acute and long-term responses to influenza A infection in mice.
Ramsey Kathryn A KA Foong Rachel E RE Sly Peter D PD Larcombe Alexander N AN Zosky Graeme R GR
Environmental health perspectives 20130822 10
<h4>Background</h4>Arsenic is a significant global environmental health problem. Exposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase the rates of bronchiectasis in early adulthood.<h4>Objective</h4>We aimed to determine if early life exposure to arsenic exacerbates the response to early life influenza infection in mice.<h4>Methods</h4>C57BL/6 mice were exposed to arsenic in utero and througho ...[more]
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