Ontology highlight
ABSTRACT:
SUBMITTER: Dourte LM
PROVIDER: S-EPMC3801205 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Dourte Leann M LM Pathmanathan Lydia L Mienaltowski Michael J MJ Jawad Abbas F AF Birk David E DE Soslowsky Louis J LJ
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20130416 9
Tendons have complex mechanical properties that depend on their structure and composition. Some studies have assessed the role of small leucine-rich proteoglycans (SLRPs) in the mechanical response of tendon, but the relationships between sophisticated mechanics, assembly of collagen and SLRPs have not been well characterized. In this study, biglycan gene expression was varied in a dose dependent manner using biglycan null, biglycan heterozygote and wild type mice. Measures of mechanical (tensio ...[more]