Ontology highlight
ABSTRACT:
SUBMITTER: Vascotto C
PROVIDER: S-EPMC3802553 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Vascotto Carlo C Cesaratto Laura L Zeef Leo A H LA Deganuto Marta M D'Ambrosio Chiara C Scaloni Andrea A Romanello Milena M Damante Giuseppe G Taglialatela Giulio G Delneri Daniela D Kelley Mark R MR Mitra Sankar S Quadrifoglio Franco F Tell Gianluca G
Proteomics 20090201 4
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through its independent activity as a redox transcriptional co-activator. Dysregulation of this protein has been associated with cancer development. At present, contrasting data have been published regarding the biological relevance of the two functions as well as the molecular mechanisms involved. Here, we ...[more]