Ontology highlight
ABSTRACT:
SUBMITTER: Cronin JC
PROVIDER: S-EPMC3803156 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Cronin Julia C JC Watkins-Chow Dawn E DE Incao Art A Hasskamp Joanne H JH Schönewolf Nicola N Aoude Lauren G LG Hayward Nicholas K NK Bastian Boris C BC Dummer Reinhard R Loftus Stacie K SK Pavan William J WJ
Cancer research 20130801 18
The transcription factor SOX10 is essential for survival and proper differentiation of neural crest cell lineages, where it plays an important role in the generation and maintenance of melanocytes. SOX10 is also highly expressed in melanoma tumors, but a role in disease progression has not been established. Here, we report that melanoma tumor cell lines require wild-type SOX10 expression for proliferation and SOX10 haploinsufficiency reduces melanoma initiation in the metabotropic glutamate rece ...[more]