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PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation.

ABSTRACT: Amphiphilic polypeptide-containing hybrid dual brush block copolymers with controlled molecular weights and narrow molecular weight distributions were synthesized in one pot via ring-opening metathesis polymerization of sequentially added norbornyl-PEG and N-(2-((trimethylsilyl)amino)ethyl)-5-norbornene-endo-2,3-dicarboximide (M1) followed by ring-opening polymerization of amino acid N-carboxyanhydrides. Polylactide nanoparticles coated with these am phiphilic dual brush block copolymers showed significantly improved stability in PBS solution compared to those coated with amphiphilic linear block copolymers such as PEG-polylactide and PEG-polypeptides.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC3804265 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation.

Zhang Yanfeng Y Yin Qian Q Lu Hua H Xia Hongwei H Lin Yao Y Cheng Jianjun J

ACS macro letters 20130901 9

Amphiphilic polypeptide-containing hybrid dual brush block copolymers with controlled molecular weights and narrow molecular weight distributions were synthesized in one pot via ring-opening metathesis polymerization of sequentially added norbornyl-PEG and <i>N</i>-(2-((trimethylsilyl)amino)ethyl)-5-norbornene-endo-2,3-dicarboximide (M1) followed by ring-opening polymerization of amino acid <i>N</i>-carboxyanhydrides. Polylactide nanoparticles coated with these am phiphilic dual brush block copo ...[more]

PMID: 24159425

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