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A cytotoxic dimeric furanoheliangolide from Piptocoma rufescens.

ABSTRACT: A new sesquiterpene lactone, rufescenolide C (1), the first furanoheliangolide dimer, was isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. Its structure was determined by analysis of its spectroscopic data, with the absolute configuration being established by analysis of the CD spectrum. A plausible biogenesis of this dimer is proposed. This compound showed potent cytotoxicity with an IC50 value of 150 nM, when tested against HT-29 human colon cancer cells.

SUBMITTER: Ren Y

PROVIDER: S-EPMC3804354 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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A cytotoxic dimeric furanoheliangolide from Piptocoma rufescens.

Ren Yulin Y Jiménez Francisco F García Ricardo R Mejía Milciades M Chai Heebyung H Farnsworth Norman R NR Soejarto Djaja D DD Kinghorn A Douglas AD

Tetrahedron letters 20131001 40

A new sesquiterpene lactone, rufescenolide C (1), the first furanoheliangolide dimer, was isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. Its structure was determined by analysis of its spectroscopic data, with the absolute configuration being established by analysis of the CD spectrum. A plausible biogenesis of this dimer is proposed. This compound showed potent cytotoxicity with an IC50 value of 150 nM, when tested against HT-29 hu ...[more]

PMID: 24159245

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